| JeniusBank (digital unit of SMBC Manubank) | Closure | SD | -- | 2 | Aug 10, 2026 | -- | |
| Conduent | Layoff | SD | -- | 1 | Jun 29, 2026 | Aug 28, 2026 | |
| Republic National Distributing Company | Closure | SD | Rapid City | 53 | May 19, 2026 | Jul 17, 2026 | |
| Christ The King School | Closure | SD | Sioux Falls | 31 | Feb 24, 2026 | May 19, 2026 | |
| Select Medical Corporation, dba Select Specialty Hospital - South Dakota | Closure | SD | Sioux Falls | 90 | Oct 9, 2025 | Nov 7, 2025 | |
| KBR [Earth Resources Observation & Science (EROS) Data Center] | Layoff | SD | Sioux Falls | -- | Oct 1, 2025 | Dec 2, 2025 | |
| Cimpl's LLC | Closure | SD | Yankton | 36 | May 30, 2025 | Jul 29, 2025 | |
| Accelerate360 Distribution, LLC – Dakota Merchandising Remote Work | Closure | SD | Sioux Falls | 324 | Apr 25, 2025 | Jun 28, 2025 | |
| Cimpl's LLC | Closure | SD | Yankton | 277 | Mar 17, 2025 | May 16, 2025 | |
| JeniusBank (digital unit of SMBC Manubank) | Closure | SD | -- | 173 | Jan 8, 2025 | -- | |
| Yelloh | Closure | SD | Aberdeen | 40 | Sep 30, 2024 | Nov 22, 2024 | |
| A&A Express | Closure | SD | Brandon | 111 | Aug 9, 2024 | Aug 16, 2024 | |
| Target Corporation | Closure | SD | Sioux Falls | 59 | May 15, 2024 | Aug 2, 2024 | |
| Neiman Enterprises, dba Spearfish Forrest Products | Layoff | SD | Spearfish | 50 | Apr 15, 2024 | Jun 12, 2024 | |
| Banner Engineering | Closure | SD | Aberdeen | 311 | Mar 1, 2024 | Dec 31, 2024 | |
| Fiserv | Closure | SD | Sioux Falls | 80 | Jan 4, 2024 | Jun 30, 2024 | |
| Transit Management of Sioux Falls, Inc. | -- | SD | Sioux Falls | 91 | Nov 8, 2023 | -- | |
| Cygnus Home Services, LLC, dba Yelloh | -- | SD | Rapid City | 10 | Oct 31, 2023 | -- | |
| Millenium Print Group | -- | SD | Howard | 85 | Sep 17, 2023 | -- | |
| Tyson Foods | -- | SD | Dakota Dunes | 262 | May 26, 2023 | -- | |
| Banner Engineering | -- | SD | Huron | 164 | Mar 8, 2023 | -- | |
| Avantara | -- | SD | Armour | 47 | Aug 8, 2022 | -- | |
| Avantara | -- | SD | Ipswich | 51 | Mar 31, 2022 | -- | |
| Aramark – SDSU | -- | SD | Brookings | 278 | Mar 17, 2022 | -- | |
| Aramark – USD | -- | SD | Vermillion | 233 | Mar 17, 2022 | -- | |
| LSC Communications LLC | -- | SD | Beresford | 53 | Feb 21, 2022 | -- | |
| Molded Fiber Glass | -- | SD | Aberdeen | 300 | Jun 7, 2021 | -- | |
| Remington Outdoor Company | -- | SD | Sturgis | 5 | Oct 7, 2020 | -- | |
| Sheraton | -- | SD | Sioux Falls | 140 | May 13, 2020 | -- | |
| Bloomin' Brands Inc. (Outback Steakhouse) | -- | SD | Sioux Falls | 70 | Apr 27, 2020 | -- | |
| EROS | -- | SD | Sioux Falls /Garretson | 400 | Apr 23, 2020 | -- | |
| Visionworks | -- | SD | Sioux Falls | 8 | Apr 4, 2020 | -- | |
| PBM Packaging Inc. (RR Donnelley) | -- | SD | Howard | 56 | Mar 4, 2020 | -- | |
| Littlelfuse Inc. | -- | SD | Rapid City | 125 | Feb 25, 2020 | -- | |
| MetaBank | -- | SD | Brookings, Sioux Falls | 74 | Nov 20, 2019 | -- | |
| Covington Care and Rehabilitation Center | -- | SD | Sioux Falls | 90 | May 31, 2019 | -- | |
| Mobridge Care and Rehabilitation Center | -- | SD | Mobridge | 67 | Nov 28, 2018 | -- | |
| TCF Bank | -- | SD | Sioux Falls | 145 | Sep 5, 2018 | -- | |
| Ditech | -- | SD | Rapid City | 39 | Aug 17, 2018 | -- | |
| Younkers (Bonton) | -- | SD | Sioux Falls | 158 | Jun 5, 2018 | -- | |
| Wells Fargo & Co. | -- | SD | Aberdeen | 108 | Mar 27, 2018 | -- | |
| Molded Fiber Glass Companies | -- | SD | Aberdeen | 409 | Feb 15, 2018 | -- | |
| Bimbo Bakeries | -- | SD | Sioux Falls | 58 | Sep 8, 2017 | -- | |
| Buhler | -- | SD | Salem | 63 | Mar 9, 2016 | -- | |
| Wyndham Hotel Group | -- | SD | Aberdeen | 241 | Sep 9, 2015 | -- | |
| Nash Finch Company | -- | SD | Rapid City | 49 | Feb 3, 2015 | -- | |
| Asurion | -- | SD | Rapid City | 227 | Nov 4, 2014 | -- | |
| Capital One | -- | SD | Sioux Falls | 750 | Jun 24, 2014 | -- | |
| Minnesota Rubber & Plastic (Quadion LLC) | -- | SD | Watertown | 171 | Nov 15, 2013 | -- | |
| Raven - Aerostar | -- | SD | Huron | 75 | Sep 20, 2013 | -- | |
| Sargento | -- | SD | North Sioux City | 39 | Jul 29, 2013 | -- | |
| Communication Services for the Deaf, Inc. | -- | SD | Sioux Falls | 43 | Apr 22, 2013 | -- | |
| Stream Global Services, Inc. | -- | SD | Vermillion | 180 | Aug 22, 2012 | -- | |
| Verifications | -- | SD | Aberdeen | 73 | May 7, 2012 | -- | |
| Verifications | -- | SD | Mitchell | 75 | May 7, 2012 | -- | |
| Hostess Brands | -- | SD | Sioux Falls | 10 | May 4, 2012 | -- | |
| Wells Fargo | -- | SD | Aberdeen | 66 | Feb 2, 2012 | -- | |
| Bosselman Travel Center | -- | SD | Rapid City | 30 | Jan 5, 2012 | -- | |
| Rockwell Collins, Inc. | -- | SD | Ellsworth Air Force Base | 8 | Oct 24, 2011 | -- | |
| Alamo Group (SMC) | -- | SD | Sioux Falls | 76 | Oct 20, 2011 | -- | |
| Premier Bankcard | -- | SD | Spearfish | 335 | May 23, 2011 | -- | |
| Communication Services for the Deaf (CSD) | -- | SD | Sioux Falls | 79 | Mar 29, 2010 | -- | |
| Verety LLC | -- | SD | South Dakota | 6 | Mar 19, 2010 | -- | |
| Terex Load King | -- | SD | Elk Point | 73 | Dec 3, 2009 | -- | |
| Terex Load King | -- | SD | Elk Point | 10 | Aug 24, 2009 | -- | |
| Coventry Healthcare Inc. | -- | SD | Aberdeen | 73 | Aug 19, 2009 | -- | |
| Wells Fargo | -- | SD | Sioux Falls | 114 | Jul 30, 2009 | -- | |
| Merillat | -- | SD | Rapid City | 158 | Jul 17, 2009 | -- | |
| VeraSun Energy Corporation | -- | SD | Sioux Falls | 92 | May 25, 2009 | -- | |
| Terex Load King | -- | SD | Elk Point | 63 | May 1, 2009 | -- | |
| Hutchinson Technology Inc. | -- | SD | Sioux Falls | 275 | Jan 8, 2009 | -- | |
| MPC | -- | SD | North Sioux City | 45 | Jan 2, 2009 | -- | |
| MPC | -- | SD | North Sioux City | 89 | Nov 5, 2008 | -- | |
| Student Financial Loan Corporation (SFLC) | -- | SD | Aberdeen | 18 | May 20, 2008 | -- | |
| Qwest | -- | SD | Sioux Falls | 58 | Jan 24, 2008 | -- | |
| Ideal Merchandising | -- | SD | Apollo Beach, FL | 1 | Dec 6, 2007 | -- | |
| Artic Cat | -- | SD | Madison | 89 | Nov 12, 2007 | -- | |
| Gateway | -- | SD | North Sioux City | 60 | Oct 11, 2007 | -- | |
| Oak Valley Farms | -- | SD | Watertown | 225 | Jul 30, 2007 | -- | |
| Gillette Dairy | -- | SD | Rapid City | 48 | May 16, 2007 | -- | |